scopulariopsis disease
At that time, no clinical evidence of acute or critical limb ischemia was present. Therefore, isolation of fungi in culture is vital for definitive identification, which is often necessary for guiding appropriate antifungal therapy. confirmed the synonymy of these mentioned species by phylogenetic analysis (1). Sporadic ocular infections have been previously reported,[11,12,22] however it is not uncommon to have a delay in the diagnosis of fungal keratitis because of occasional difficulty in collecting the corneal samples as well as isolating and identifying the pathogenic fungus. The fungal identification was performed after culture of the removed valve and/or on embolus. The patient had no significant past medical history and was an occasional cosmetic soft contact lenses wearer. Regarding the Scopulariopsis species, the reports include 2 patients infected by S. acremonium, one by S. candida, one by S. brevicaulis, and 3 by Scopulariopsis spp. Before Conidia were 5 to 8 m in size, round, light brown in color, and with truncated bases (Fig. In conclusion, Scopulariopsis endocarditis is a rare disease that is challenging to treat due to its resistance to broad-spectrum antifungal agents. Accessibility While these are features most frequently associated with Aspergillus species, they are also common to other hyaline fungal pathogens such as Fusarium spp. Generally, effective preventive measures remain the cornerstone in combating CLMK. 2023 American Medical Association. Bonifaz A, Cruz-Aguilar P, Ponce RM. The conidia are 5 to 8 m in size, round, and light brown in color. Histopathologic examination of the ascending aortic tissue and left iliac artery embolus and thrombus utilizing hematoxylin and eosin (H&E) stain, Gomori methenamine silver (GMS) stain, and periodic acid-Schiff stain (PAS) revealed numerous septate hyphae with dichotomous branching (Fig. 2). J Clin Microbiol. The infection showed signs of satisfactory clinical resolution. HHS Vulnerability Disclosure, Help The authors declare no conflict of interest. Lubricating eye drops were continued hourly. Iwen PC, Schutte SD, Florescu DF, et al. While blood cultures remain the most important indication of the much more common entity of bacterial endocarditis, they have a limited role in the diagnosis of fungal endocarditis since less than 50% of reported cases demonstrated positive blood culture results (6, 7). Conceptualization: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Data curation: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Formal analysis: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Investigation: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Methodology: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Project Administration: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Resources: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Software: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Supervision: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Validation: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Visualization: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Writing original draft: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, Writing review & editing: Nasser M. Kaplan, Rami A. Al-Dwairi, Nasr N. AlRabadi, contact lens; keratitis; Scopulariopsis brevicaulis. Activity of antibiotics against. Rao et al[18] described 12 patients with Fusarium keratitis, 4 of whom (33%) were cured with a combination of antibiotics consisting of a fluoroquinolone agent (levofloxacin or ofloxacin), tobramycin, and vancomycin. Fungal sinusitis can also occur in immunocompetent patients; however, the reported cases are extremely rare. Sinonasal infections caused by Scopulariopsis spp. 2018 Dec;108(6):658-664. doi: 10.1007/s12185-018-2496-1. A focus of this report is the diagnostic methods utilized which included histopathology and culture with both micromorphologic and genotypic procedures employed to confirm the species identification. Eighteen days after the mold was identified, the antifungal MIC results were received and reported as follows: amphotericin B, 4 g/ml; micafungin, 0.5 g/ml; posaconazole, 1 g/ml; voriconazole, 2 g/ml; isavuconazole, 2 g/ml. The .gov means its official. government site. Kurata K, Nishimura S, Ichikawa H, Sakai R, Mizutani Y, Takenaka K, Kakiuchi S, Miyata Y, Kitao A, Yakushijin K, Kawamoto S, Yamamoto K, Ito M, Matsuoka H, Tokimatsu I, Kamei K, Minami H. Int J Hematol. An official website of the United States government. Federal government websites often end in .gov or .mil. Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Fatal Scopulariopsis brevicaulis infection in a paediatric stem-cell transplant patient treated with voriconazole and caspofungin and a review of Scopulariopsis infections in immunocompromised patients. The fungal culture post-lobectomy revealed Scopulariopsis spp. Ophthalmic Res 2014;52:4352. Google Scholar. All fortified eye drops were discontinued and replaced by moxifloxacin (fluoroquinolone) eye drops 4 times daily. You may search for similar articles that contain these same keywords or you may One Scopulariopsis fungal ball was described in a 67-year-old patient, case in which the infection was localized in the middle pulmonary lobe. National Library of Medicine The authors confirm that the data supporting the findings of this study are available within the report. [39], In this case, the patient was continued on antibacterial therapy because of the noticed satisfactory clinical response, the relatively delayed fungal growth, and to avoid the well-known toxic effects of antifungal agents particularly associated with the required long therapeutic duration. Proper identification of these pathogens requires sporulating culture, which considerably delays the diagnosis. [9]. Current commercial topical preparations of fluoroquinolones demonstrated a definite antifungal activity against Fusarium and Candida isolates from human ocular infections. 1 Altmetric Metrics Abstract Background Microascus cirrosus, the teleomorph of Scopulariopsis spp., is a saprobic species with a worldwide distribution and rarely causes human infection. 1996 May;35(5):257-60. doi: 10.1177/000992289603500505. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorales organisms) in a 12-year-old girl who was being treated for non-Hodgkin's lymphoma. Unable to load your collection due to an error, Unable to load your delegates due to an error. Fungal endocarditis is most prevalent in patients who are immunocompromised, intravenous drug abusers, recipients of prolonged antibiotic therapy, recipients of parenteral nutrition, and recipients of prosthetic heart valves and in those who have undergone reconstructive cardiac surgery (6). This case is compared with 32 prior cases of proven invasive Scopulariopsis (Microascus) infections reported in the literature. Ustun C, Huls G, Stewart M, Marr KA . CLMK requires urgent treatment to contain damage and to improve prognosis, however it usually poses a clinical diagnostic dilemma as the distinction between sterile inflammation and microbial infection is often unclear. should immediately prompt antifungal susceptibility testing to select the best antifungal regimen. The Scopulariopsis genus comprises cosmopolite and common saprophytic filamentous fungi. Bookshelf VisualDx - Scopulariopsis Please try after some time. Bookshelf Deep infection with this fungus is associated with a high mortality rate. Bone Marrow Transplantation 1). The diagnosis and management of, [5]. 2012 Aug;50(6):561-9. doi: 10.3109/13693786.2012.675629. Contact lens wear remains the most common predisposing factor. Fungal keratitis due to Scopulariopsis brevicaulis and a potential promising therapeutic effect of antibacterial agents: a case report. 2). Rapid Assays for Specific Detection of Fungi of Scopulariopsis and You may be trying to access this site from a secured browser on the server. The Authors. Please try again soon. There have been anecdotal reports of fungal ulcers that improved with antibiotic treatment alone. Schlemmer F, Lagrange-Xelot M, Lacroix C, de La Tour R, Socie G, Molina JM . An important limitation in this case was that the CML did not receive glass slides smeared with the aseptically collected corneal scrapings for preliminary diagnostic staining techniques. Scopulariopsis is a filamentous fungus that inhabits soil, plant material, feathers, and insects. [9,30,31] Antifungal therapy alone rarely achieves a cure and other therapeutic interventions, as debridement or excision of necrotic tissue, are also required. should immediately prompt antifungal susceptibility testing to select the best antifungal regimen. This report describes the first case of fatal disseminated Scopulariopsis brumptii in a pediatric patient with hyper-IgM syndrome status post bone marrow transplant. Antifungal amphiphilic kanamycins: new life for an old drug. An official website of the United States government. Nixon HK. 2011 Jul;75(7):891-3. doi: 10.1016/j.ijporl.2011.03.026. Disseminated Scopulariopsis brevicaulis infection in an allogeneic stem cell recipient. Dark-colored soil debris from underneath the distal edges of the long fingers nails of the patient was also collected and cultured. 2020 Feb 1;58(2):145-155. doi: 10.1093/mmy/myz036. official website and that any information you provide is encrypted Ellison MD, Hung RT, Harris K, Campbell BH. In fungal keratitis, the surgical debridement of corneal ulcer helps to significantly reduce the load of infecting fungus and enhance the penetration of topical therapeutic agents.[32]. JAMA Ophthalmol 2013;131:4229. Chicken Intestinal Mycobiome: Initial Characterization and Its Response to Bacitracin Methylene Disalicylate. In addition, the identification of an unusual mold should immediately prompt susceptibility testing since susceptibility patterns have not been well established for many infrequently isolated molds. The diagnosis of fungal endocarditis is often challenging to make clinically due in part to inconsistent and nonspecific clinical presentations. For example, the species of Scopulariopsis, is an uncommon cause of invasive disseminated infections but are still recognized as relatively common opportunistic causes of keratitis, onychomycosis, and otomycosis. Epub 2016 Mar 29. The authors have no funding and conflicts of interest to disclose. The patient underwent thrombectomy and resection of ascending aortic graft tissues, portions of which were submitted for histopathological and microbiological analysis. Guevara-Suarez M, Llaurado M, Pujol I, Mayayo E, Martin-Vicente A, Gen J. Mycopathologia. Scopulariopsis acremonium is a species of saprophytic fungus not previously reported to cause invasive disease in humans, although invasive infections from other species of Scopulariopsis have been reported and are reviewed. For more information, please refer to our Privacy Policy. PubMed Careers. Sattler L, Sabou M, Ganeval-Stoll A, Dissaux C, Candolfi E, Letscher-Bru V. Med Mycol Case Rep. 2014 Jun 4;5:24-7. doi: 10.1016/j.mmcr.2014.05.003. Keay L, Stapleton F. Development and evaluation of evidence-based guidelines on, [4]. Scopulariopsis species cause a broad range of disease, from superficial skin infections to often fatal disseminated disease in the immunocompromised that is refractory to standard antifungal treatment. Scopulariopsis and Microascus spp. Epub 2019 Aug 7. Following reporting of these findings, the antibacterial therapy was discontinued after a total of 4 days and intravenous amphotericin B (65 mg q24h) was added to the antifungal regimen pending antifungal susceptibility data. Wolters Kluwer Health 8600 Rockville Pike In the present paper, we present the first case of primary cutaneous M. cirrosus infection in a Chinese female. Serial CTA imaging follow-up at 4 months and 12 months postoperatively demonstrated a stable aortic root and ascending thoracic aorta and stable aortobiiliac bypass graft with no signs of complications.
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