advances in immunology research impact factor
V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors. Journal metrics This page provides journal profiles, turnaround times, citation distributions, and citation-based metrics for the Science family of journals and is updated on a semi-annual basis. Immunol. 39, 3543 (2018). Depending on the affected pathway, PIDs are associated with varying levels of severity, times of onset, and risks of infection by certain groups of microorganisms. Trends Immunol. Sivori, S. et al. Since its inception, this therapy has been improved markedly, with an increase in optimal responses from less than 30% to the current 5075%, in some cases. . IL-10-secreting regulatory T cells do not express foxp3 but have comparable regulatory function to naturally occurring CD4 + CD25 + regulatory T cells. Drug Des. The mechanisms underlying the establishment of this innate immune memory differ from those involved in adaptive immune memory81. 17, 665678 (2017). 216, 12441254 (2019). Pharm. 16, 430441 (2019). Advances in the assessment and control of the effector functions of therapeutic antibodies. Rep. Urol. Old with Mycobacteria, bacillus Calmette-Gurin (BCG) was approved by the American Food and Drug Administration (FDA) in 1976 for use in a therapeutic procedure for bladder cancer a treatment that is still in use today185,186. Allergen extracts can be obtained from different sources, such as cat hair and pelt, mites, different types of pollen, venom protein, foods, etc. Ubiquitination involves three main steps: activation, conjugation and ligation, which are performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s). Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy. Research Impact Score: 0.40. The concept of immune tolerance is defined as the ability of the immune system to prevent the targeting of self-molecules, self-cells or self-tissues. Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors. 39, 627642 (2017). Immunol. Prominent examples include illnesses produced by Mycobacterium tuberculosis, human immunodeficiency virus (HIV), Plasmodium falciparum orthe current coronavirus disease 2019 (COVID-19) outbreak caused by thesevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has already infected millions of people and produced thousands of deaths in many countries. Adv. OSullivan, T. E. et al. Eur. Front. J. 1, 365372 (1994). Sun, Z. et al. Gulati, A., Kaur, D., Krishna Prasad, G. V. R. & Mukhopadhaya, A. PRR function of innate immune receptors in recognition of bacteria or bacterial ligands. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Knowledge of how to handle trained immunity will enable better vaccine design and more effective secondary responses326. Nat. Vivier, E. et al. PubMed J. Vidal, S. M., Malo, D., Vogan, K., Skamene, E. & Gros, P. Natural resistance to infection with intracellular parasites: isolation of a candidate for BCG. 369, 20130433 (2014). Immunol. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Article Lurie, N., Saville, M., Hatchett, R. & Halton, J. Cytokine-induced memory-like natural killer cells. In some human clinical trials, remission has been observed for patients with acute myeloid leukemia271,272, which broadens the options for the use of NK cells in the treatment of this pathology. 118, 54968 (2016). J. Intern. China and the USA are the leading countries in producing CAR T-cell therapy, and numerous clinical trials are underway. Herberman, R. B., Nunn, M. E., Holden, H. T. & Lavrin, D. H. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. Semin. Mitoma, H., Horiuchi, T., Tsukamoto, H. & Ueda, N. Molecular mechanisms of action of anti-TNF- agents - Comparison among therapeutic TNF- antagonists. Moreover, new subsets of regulatory T cells have been described. Although the main barrier for long-term organ and tissue grafting is driven by HLA incompatibilities, other important players play roles in transplant rejection. https://doi.org/10.1038/s41431-020-0691-z. J. Immunol. Immunotherapy Advances is now indexed in PubMed Central and Scopus. Int. Shawler, D. L., Bartholomew, R. M., Smith, L. M. & Dillman, R. O. Pagani, M. et al. Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Ahn, J. Y. et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. Proc. Cell 174, 10541066 (2018). 8, 499541 (2019). Int. Knowledge of these two checkpoint inhibitors has opened the door to new antitumoral therapeutic approaches, such as the use of monoclonal antibodies that block the aforementioned interactions (anti-PD1, anti-PD-L1, or anti-CTLA-4), which are called checkpoint inhibitors176. Proliferating dendritic cell progenitors in human blood. The mAb, after binding to a target cell, can attach to Fc receptors on the surface of NK cells to trigger the release of granzymes and perforin, thus inducing cell target death243,244. Meyer, H., Ehmann, R. & Smith, G. L. Smallpox in the post-eradication era. Lab. Non-specific effects of vaccines: current evidence and potential implications. Ubiquitination is a process that marks proteins for degradation via the proteasome, which is required for the processing of intracellular antigens (such as virus proteins or mutated tumor proteins) and their presentation by class I HLA molecules. fr Pathol. Exp. Annu. Trends in Immunology plays an essential role in monitoring advances in the various fields of immunology, bringing together the results in a readable and lucid form. Microb. 216, 728742 (2019). 17, 179186 (2016). Piontek, G. E. et al. Eyerich, S. et al. Ther. Abrahamsson, T. R. et al. Some of the most common autoimmune diseases include type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease (https://www.aarda.org/diseaselist/). Edholm, E.-S. et al. The roles of ILCs in immunity and their cross talk with other components of the immune response await further analysis. Durrant, W. E. & Dong, X. You, J. H. S., Jiang, X., Lee, W. H., Chan, P. K. S. & Ng, S. C. Cost-effectiveness analysis of fecal microbiota transplantation for recurrent Clostridium difficileinfection in patients with inflammatory bowel disease. Serra, P. & Santamaria, P. Nanoparticle-based approaches to immune tolerance for the treatment of autoimmune diseases. Becattini, S. et al. Vieira, P. L. et al. Large variability in terms of remission and durable clinical benefits between patients is observed (for example, in the antitumoral responses by antibodies directed to the checkpoint inhibitors). PubMed demonstrated that pattern recognition receptors (PRRs) expressed on innate cells recognize invariant molecular structures expressed by invading pathogens82. Google Scholar. MAbs 10, 159165 (2018). J. Korean Med. Belkaid, Y. Tools and approaches to ensure quality of vaccines throughout the cold chain. In 1997, Medzhitov et al. Current Opinion in Immunology | Journal - ScienceDirect Exp. Special therapies have not yet been identified to cure these patients, and preventive vaccines are not yet available, but some immunotherapies have been proposed as adjunct therapies, and some of these are currently in different phases of clinical trials312. 8, 6672 (2009). Future Oncol. Genes affected in this group are MEFV (Mediterranean fever pyrin innate immunity regulator), which is related to familial Mediterranean fever (FMF); NLRC4 (NLR family CARD domain-containing 4); NLRP1 (NLR family pyrin domain-containing 1) and WDR1 (WD repeat domain 1)159. The specificity and the capacity to generate long-lived memory cells are two properties that have been classically used to distinguish innate immunity from adaptive immunity. On the other hand, NK cell cytotoxicity is maintained in centenarians, and an increase in the number of these cells is observed in healthy aging people177. The data indicate that the therapy is well tolerated and has led to increased patient survival in some trials. The immune system is a fascinating world of cells, soluble factors, interacting cells, and tissues, all of which are interconnected. Momp, S. M. & Gonzlez-Fernndez, . Antigen-specific human monoclonal antibodies from transgenic mice. Rev. This work was financially supported by the Ministerio de Economa y Competitividad (BIO2017-84974-R), Xunta de Galicia Grupo Referencia Competitiva 2016 (ED431C 2016/041) and the European Union (European Regional Development Fund, Ref. Immunity publishes papers that report the most important advances in immunology research. 119, 35733585 (2009). & Benacerraf, B. Klin. Curr. Th1 cells produce IFN- and express T-bet56; Th2 cells are characterized by IL-4, IL-5, and IL-13 production and GATA-3 expression57,58; pTregs, which are induced in the periphery from nave precursors, produce TGF- and express Foxp3 (Tr1 cells are IL-10-secreting Tregs that do not express Foxp3)59. What are the mechanisms that lead to a break in tolerance? Opin. New generations of CARs, including the CD3 subunit together with other signaling domains, such as CD28, CD134, CD137 (41BB), CD27, and ICOS, or combinations (CD3 , CD28, and CD134)301, have been developed in the second and third generations of CARs to improve several aspects, such as the activation, proliferation and survival of CAR T cells. Blocking activation signals. However, many of OVs have shown limited therapeutic effects when applied in monotherapy; therefore, much more work is required to improve their systemic antitumor effects and avoid the attenuation of the virus, which limits the viral replication. Immunol. In an autoimmune pathology such as multiple sclerosis, the intention is to achieve stable tolerogenic dendritic cells that can act against some autoantigens (such as myelin peptides) in the presence of vitamin D3, dexamethasone, or other agents285. Cancer 8, 473480 (2008). Numerous different mouse and rat mAbs were produced against several molecules, but due to their murine origin, patients treated with these mAbs suffered from hypersensitivity and immune responses222,223. & Zajac, A. J. T-cell exhaustion: characteristics, causes and conversion. & Hertzog, P. J. Antitumour actions of interferons: implications for cancer therapy. Nat. J. Exp. Nat. -Glucan derived from Aureobasidium pullulans is effective for the prevention of influenza in mice. 22, 680690 (2016). ILC1 confer early host protection at initial sites of viral infection. In addition to the use of convalescence plasma, hyperimmune globulin therapy or monoclonal antibodies directed against the virus have also been proposed, and clinical assays are ongoing. In turn, the faster and more pronounced reactivity of adaptive immune cells (T and B lymphocytes) upon reinfection is characterized by permanent changes in the genome of cells, such as mutations, gene rearrangement, clonal expansions, as well as epigenetic modifications, all of which ensure a more persistent effect than is endowed by trained immunity81,94,95. The characterization of new immune cell subsets has been a constant feature in the immunology field. CAS Systemic acquired resistance. However, PIDs are broadly classified as follows according to the component of the immune system affected: T-cell immunodeficiency, e.g., defects in the IFN-/IL-12 pathway and mutations in the autoimmune regulator (AIRE) gene. Clin. In the meantime, to ensure continued support, we are displaying the site without styles Gonzlez-Serna, D. et al. In contrast, NCR2 ILC3s can promote colitis in a model of inflammatory bowel disease25. It has been proposed that this basal inflammatory state contributes to the development of some diseases, such as Type II diabetes, Alzheimers disease and atherosclerosis178. J. Clin. 186, 56485655 (2011). Low gut microbiota diversity in early infancy precedes asthma at school age. 197, 276277 (2019). CAR T cells in solid tumors: blueprints for building effective therapies. Mazmanian, S. K., Liu, C. H., Tzianabos, A. O. & Hughes, C. C. W. Of mice and not men: differences between mouse and human immunology. The development of different types of immunotherapies, including vaccines (prophylactic and therapeutic), and the use of pathogens, monoclonal antibodies, recombinant proteins, cytokines, and cellular immunotherapies, are changing the way in which we approach many diseases, especially cancer. PubMed When it binds to its ligand on tumor cells, PD1 inhibits tumor cell apoptosis, causes peripheral effector T-cell exhaustion, and promotes the conversion of effector T cells into regulatory T cells172,174. After interacting with CD19+ cells, these modified CAR T cells were activated and able to proliferate and exert cytotoxic functions against target cells. & de Jong, E. C. Dendritic cell science: more than 40 years of history. The journal is brought to you by the British Society for Immunology and edited by world leading immunologist Professor Tim Elliott, supported by a global editorial board of experts from academia and industry. Immunol. Expansion of a unique CD57+ NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Chester, K. A. et al. Blood Marrow Transpl. A subpopulation of DCs also carries out a process known as cross-presentation. In 1985, Piontek et al. Allergy Clin. Keywords: Radiation, Immunotherapy, cell therapy, immunogenic, Bridging. This journal offers the option to publish open access. B., Felices, M., Verneris, M. R. & Miller, J. S. Natural killer cell adoptive transfer therapy. Rosser, E. C. & Mauri, C. Regulatory B cells: origin, phenotype, and function. PubMed Central 159, 148158 (2010). YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage. Dtsch. IgG/IgM antibodies activate the complement cascade by the classical route, which leads to the death of the targetcell241,242. Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Finally, the loss of function due to variants of the TNFAIP3 (TNF-alpha-induced protein 3, also known as A20) gene, which encodes a protein with ubiquitin ligase and ubiquitinase activity, has also been described159. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Front. Abatacept is a competitive inhibitor that blocks T-cell activation and can be used in the treatment of inflammatory illnesses such as rheumatoid arthritis261. Ruella, M. & Kenderian, S. S. Next-generation chimeric antigen receptor T-cell therapy: going off the Shelf. Int. 35, 585599 (2015). Benetti, E., et al. & Valenta, R. Recombinant allergens for immunotherapy. It is clear that certain viruses and bacteria play roles in cancer development. Immunol. Pannemans, K., Hellings, N. & Stinissen, P. Therapeutic vaccines for autoimmune diseases. This evolution is clearly reflected in the discovery of an innate counterpart of T lymphocytes, collectively named innate lymphoid cells (ILCs)6, and in the identification of different types of effector CD4 and regulatory T cells7. PubMed Arch. Cho, J. H., Collins, J. J. Charych, D. H. et al. Annu. Ruderman, E. M. & Pope, R. M. The evolving clinical profile of abatacept (CTLA4-lg): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis. Conlon, K. C., Miljkovic, M. D. & Waldmann, T. A. Cytokines in the treatment of cancer. Cancer Immunology, Immunotherapy | Home - Springer Knochelmann, H. M. et al. PLoS ONE 13, e0208922 (2018). A. und Physiol. J. Immunol. In 1986, the FDA approved human IFN-2a and IFN-2b for patients with hairy cell leukemia and later onfor patients with multiple sclerosis. The epigenetic landscape is specific for a given cell; thus, EWAS requires careful selection of the relevant cell type for a given biomedical condition. Nakagawa, H., Wang, L., Cantor, H. & Kim, H. J. Sci. Genetically speaking, these are hereditary disorders, andto date, more than 40 genes (Table1) have been identified as causes of AIDs, which can be grouped according to the pathway that is altered159. Bioanal. Cookson, W. O., Sharp, P. A., Faux, J. Other challenging aspects of cellular immunotherapy are the life-threatening toxicity of induced and their lack of effect on solid tumors, which is mostly due to the immunosuppressive tumor microenvironment. npj Vaccines 2, 12 (2017). NK cell adoptive transfer (either autologous or allogenic NKs) is currently being tested in clinical trials for hematological diseases and solid tumors, and numerous research groups have recognized their potential in other situations, such as transplant rejection and pregnancy.
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