should you take hyaluronic acid on an empty stomach
Joint Bone Spine. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Boswellia, also known as Indian frankincense, is an herbal extract taken from the Boswellia serrata tree. In addition to being a topical agent, hyaluronic acid is also available for oral consumption. Say Hello to Hyaluronic Acid - Better Nutrition Health Benefits of Hyaluronic Acid - WebMD Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study. This is a key step in how wounds heal on your body. Hyaluronic acid (HA), also called hyaluronan , is a substance naturally found throughout your body, including the skin, eyes, and joints. 2022;270:239-245. doi:10.1016/j.ejogrb.2022.01.021, Altman R, Hackel J, Niazi F, Shaw P, Nicholls M. Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review. Analytical cookies are used to understand how visitors interact with the website. Store HA supplement in a cool, dry place and keep HA away from direct sunlight. Verywell Health's content is for informational and educational purposes only. But the benefits can last from 6 months to a year. In a small study, it was found that hyaluronic acid can improve skin elasticity and reduce skin redness in as little as two to eight weeks. While more high quality, recent research in humans is needed, early animal and test-tube studies are promising. Pediatric Pulmonology. If you have skin infections, knee joint infections, or any other issue around the hyaluronic acid injection site, tell your doctor right away. Hyaluronic acid supplements can help your skin look and feel more supple. Joint pain, discomfort or swelling, especially after an injury. It is rare that it may cause an allergic reaction. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. Hyaluronic acid is approved for use in some eye operations. When the long molecule breaks down into small fragments, its referred to as low molecular weight HA (LMWHA). Its also the topic of hundreds of scientific studies and trials around the world. Effects of hyaluronic acid on bleeding following third molar extraction. . Should you take hyaluronic acid orally? 5 For skin wrinkles, studies have used a dose of 120 milligrams (mg) by mouth daily for 12 weeks. The information provided is not intended for use as medical advice, diagnosis, or treatment. One of its important functions is acting as a free radical scavenger. Suggested dose: For thumb osteoarthritis, the dose is 5 milligrams (mg) for one cycle of three injections (one per week). Becker LC, Bergfeld WF, Belsito DV, et al. Is Hyaluronic Acid Good or Bad? - Skin Care Geeks 2020;18(3):268-277. doi:10.1111/idh.12432, Kim JS, Lee SS, Kim TJ, Park YW. This lab-made version can help with a variety of bodily functions. Dos Santos CCM; Uggioni MLR; Colonetti T; Colonetti L;Grande AJ; Da Rosa MI; Hyaluronic acid in postmenopause vaginal atrophy: A systematic review. Sources of Hyaluronic Acid & What to Look For, Why Im Actually Excited For Rituals Newest Supplement for Skin Health, HyaCera, Supartz Injections for Knee Osteoarthritis, Synvisc and Synvisc-One Use and Side Effects. Earth Clinic Team | Modified on May 29, 2022 Add New Post 146 Comments Hyaluronic Acid (HA) has become a popular supplement used to treat many ailments. 9 Best Hyaluronic Acid For Horses Reviews. Be sure to inform your healthcare provider about all supplements and medicines you take. A pilot study. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Topical application of creams, gels, and lotions containing phytoestrogens (plant-based estrogens) for 12 to 24 weeks has increased hyaluronic acid levels. Yes, that's right! Wounds. International Journal of Molecular Sciences. There is a substance in the kidneys. Boswellia: Uses, Dosage, Side Effects, and More - Healthline 18 1 5 What Is Carnosine? Some older test-tube studies have also shown that high doses of hyaluronic acid can increase the activity of osteoblasts, the cells responsible for building new bone tissue (42, 43). How long does it take for hyaluronic acid to work? 2020;243:116441. doi:10.1016/j.carbpol.2020.116441, Gupta RC, Lall R, Srivastava A, Sinha A. Hyaluronic acid: molecular mechanisms and therapeutic trajectory. But opting out of some of these cookies may affect your browsing experience. It can also help people with dry eyes. HYALURONIC ACID - Uses, Side Effects, and More - WebMD However, do consult your doctor and follow package instructions. It is rare that it may cause an allergic reaction. Severe headache or stomach pain. I take 40 mg of lasix daily for my BPdoes wonderful for BP.but did cause hair loss, brittle, splitting nailsI upped my Hyaluronic acid supplement from 1 tab 250 mg to 2 tabletsno more nails splitting, hair loss significantly lessit's for me for sure. Skin Research and Technology. (3). 2019;6. doi:10.3389/fvets.2019.00192, Lephart ED, Naftolin F. Menopause and the skin: old favorites and new innovations in cosmeceuticals for estrogen-deficient skin. The effect of combination therapy (glucosamine, chondroitin, and HA) on knee osteoarthritis has been studied. Regulation and roles of the hyaluronan system in mammalian reproduction. Hyaluronic acid statpearls NCBI bookshelf. Read our, Joint Function and Pain in Osteoarthritis. A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome. This is because about 90% of it is metabolized and eliminated via expiration and urine. What is the best way to take hyaluronic acid? 3. Published March 2017. Nonetheless, conflicting results regarding the serious side effects of HA injections have also been reported. Journal of Medicinal Food. Inflammation is one of the leading drivers of many common diseases. Rheumatology International. Taking 80200 mg daily for at least 2 months has been shown to significantly reduce knee pain in people with osteoarthritis, especially those between the ages of 40 and 70 years old (23, 24). Vision changes. Yes. Should Collagen Be Taken With Or Without Food. doi:10.1186/s13063-021-05053-7, Majeed M, Majeed S, Narayanan NK, Nagabhushanam K. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729158/. Hyaluronic acid is well known for its skin benefits, especially alleviating dry skin, reducing the appearance of fine lines and wrinkles, and speeding up wound healing. Food and Drug Administration. It does not cause sun sensitivity by itself. Resin made from boswellia extract has been used for centuries in Asian and African. The difference in the molecular weight of HA can mean different effects. Hyaluronic acid: Uses, side effects, and risks - Medical News Today Intravesical hyaluronic acid, a treatment inserted directly into your bladder, might ease both the urge to pee and the pain linked to IC/PBS. Hyaluronic acid is generally safe, although some conditions require caution. No serious side effects were reported in several randomized controlled trials and cohort studies when HA was given as an injection into the joint, taken by mouth, or applied topically to the skin. Zinc Supplement (Oral Route, Parenteral Route) Precautions - Mayo Clinic These cookies will be stored in your browser only with your consent. Thus, it is highly recommended for people with a history of cancer to avoid its use. Privacy Policy and Terms of Service apply. Consult your doctor before taking Hyalgan if pregnant . Hyaluronic acid may be the answer to wrinkle-free skin but not all varieties are equal. Hyaluronic Acid: What It Is, Benefits, How To Use & Side Effects Home > Nutrition > How to Take Hyaluronic Acid Supplement and Why. However, since oral supplements boost the levels of hyaluronic acid found in the skin, its reasonable to suspect they may provide some benefit. (https://pubmed.ncbi.nlm.nih.gov/32517278/). In a double-blind, randomized, placebo-controlled study of 60 Japanese people aged 22 to 59 who had crow's feet wrinkles (wrinkles near the corner of the eyes), taking 120 milligrams (mg) of HA in capsule form by mouth per day for 12 weeks decreased skin wrinkles. Many are available over-the-counter. Over the past 15 years, HA has been observed to induce varying effects in kidney injury and disease that are influenced by the study model. 9. Last Updated January 22, 2021 Glucosamine and chondroitin are compounds found naturally in cartilage. Hyaluronic acid also has antibacterial properties, so it may help reduce the risk of infection when applied directly to open wounds (19, 20). Thus, LMWHA may be more favorable when applied to the skin (topically). Additionally, the improvement due to HA injections was more prolonged, persisting after six months. Hyaluronic Acid and Controlled Release: A Review. Some factors that reduce the amount of HA in the body include aging, solar ultraviolet radiation, smoking, and air pollutants. It is possible to incorporate extra amounts into the body with the help of supplements. Hyaluronic acid also plays a key role in wound healing. (https://pubmed.ncbi.nlm.nih.gov/24178484/). What is hyaluronic acid? Coughing up blood. It plays a role in skin health, wound healing, bone strength, and many other other bodily systems or functions. Hyaluronic acid is generally well-tolerated and plays a role within the cosmetic, nutraceutical, and food industries. This cookie is set by GDPR Cookie Consent plugin. There has been some limited research into combinations of hyaluronic acid and other medications to treat acne, but so far, there isnt much evidence that these are effective. doi:10.1186/1475-2891-13-70, Oe M, Sakai S, Yoshida H, et al. The benefits of coconut, argan, tea tree and more. Sometimes hyaluronic acid can cause an allergic reaction. Because of its biocompatibility (meaning it's not . The supplement is safe to take and adverse effects are rare. Its a versatile molecule and scientists are still finding new and beneficial ways to use it. According to one 2014 study, doses of 120240 milligrams (mg) per day for at least 1 month have been shown to significantly increase skin moisture and reduce dry skin in adults (3). Common side effects of Hyalgan include pain at the injection site, swelling of the knee, rash, itching, headache, nausea, vomiting, upset stomach, and diarrhea. We also use third-party cookies that help us analyze and understand how you use this website. Chondroitin Sulfate: Benefits, Downsides, Dosage, and More - Healthline Hyaluronic Acid Benefits: Skin Care and More! - Earth Clinic 2019;73(6):38-49. doi:10.5604/01.3001.0013.5776, Ibraheem W, Jedaiba WH, Alnami AM, et al. Thus, HA has gained traction within the beauty industry. In some older studies, applying it to skin wounds has been shown to reduce the size of wounds and decrease pain faster than a placebo or no treatment at all (15, 16, 17, 18). Warfarin side effects: Watch for interactions - Mayo Clinic Why Science Says Hyaluronic Acid Is the Holy Grail to Wrinkle-Free, Youthful Hydration, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Nutrition Journal. This can cause sensitivity and pain. Interstitial cystitis or painful bladder syndrome (IC/PBS) happens when your bladder walls become inflamed and irritated. It may take 12 months of regular use to see results. Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. You also have the option to opt-out of these cookies. In addition to being present in articular cartilage (tissue at the ends of bones) and synovial fluid (protective liquid in between your joints), HA is also usually present in the bone marrow of mammals. doi:10.1186/s12937-016-0128-2, Simental-Menda M, Snchez-Garca A, Vilchez-Cavazos F, Acosta-Olivo CA, Pea-Martnez VM, Simental-Menda LE. Healthline Media does not provide medical advice, diagnosis, or treatment. Trang Tran, PharmD, is a pharmacist who is passionate about integrative health. Dietary supplements are not strictly regulated in the United States, making it difficult to know which brands are reliable and which are not. When its taken by mouth, its very safe. However, recent studies have shown some types of cancer cells to be sensitive to hyaluronic acid. summary. Eating Foods With Flavanols May Help Boost Your Memory, What to Know About Vodka: Calories, Carbs, and More. Medicine. It can lower inflammation and speed up healing from surgery. Joint health, especially for treating arthritis and soft tissue injuries. 2023 Healthline Media LLC. What Vitamins Should Not be Taken Together? | Vitacost Blog While applying them directly to the eyes has been shown to reduce dry eye symptoms and improve overall eye health, it is unclear whether oral supplements have the same effects. Fouladi-Nashta AA, Raheem KA, Marei WFA, et al. Randomised clinical trial: Mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation. Contact lenses that contain slow-release hyaluronic acid are also being developed as a possible treatment for dry eye (34, 35, 36). It has to sit on the top layer of your skin to keep it moist and not evaporate from your skin barrier. It can also help relieve joint pain in people with osteoarthritis. 7 Healthy Foods That Are High in Hyaluronic Acid (8) It may cause their growth and spread. It might take many shots before you notice results. It may help improve your blood sugar response to foods, as well as reduce your appetite. Product classification. Research in this area is still relatively new, and more studies are needed to replicate these results. 2015;82(2):116-121. doi:10.1016/j.jbspin.2014.08.008, Hsu TF, Su ZR, Hsieh YH, et al. By clicking Subscribe, I agree to the WebMD, Benefits of Hyaluronic Acid for Bones and Joints, Potential Benefits of Hyaluronic Acid for Acid Reflux, Potential Benefits of Hyaluronic Acid for Bladder Pain. Scientists can also make it in a lab through from bacteria. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. Glucosamine supplements are popular but controversial. This website uses cookies to improve your experience while you navigate through the website. One study showed people who took hyaluronic acid and chondroitin sulfate supplements along with acid-reducing drugs had fewer acid reflux symptoms than those who only took acid-reducing drugs. Carbohydrate Polymers. Oranges. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Like any medication or supplement, its important to talk to your healthcare provider before incorporating hyaluronic acid into your healthcare regimen. If you must take both, experts generally recommend spacing them out by at least two hours. Do Glucosamine Supplements Work for Arthritis? There are no known side effects of using hyaluronic acid supplement in recommended doses. 7 Best Hyaluronic Acid With Food Or Empty Stomach Hyaluronic acid is a natural polysaccharide touted for its use in osteoarthritis, skin wrinkles, and dry eyes. But there's a better way. Many health benefits can be achieved with the use of Hyaluronic acid supplements. How Can I Use Hyaluronic Acid On My Face? It also has the ability to attach itself to cells, which is why targeted delivery of medications using hyaluronic acid is a major topic of study. Published October 2017. Funding from a company that makes hyaluronic acid supplements could have influenced the results. In case of a medical concern or emergency, please consult your healthcare provider. The theory is that as we age, the body produces less hyaluronic acid, which lubricates the cartilage between joints. Expert Opinion on Drug Metabolism & Toxicology. That's why it's better to stay with the same medication if possible. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information. New research shows hyaluronic acid supplements may help reduce symptoms of acid reflux. This disorder causes abdominal pain and tenderness, along with a strong and frequent urge to urinate (45). Bruising that develops without a remembered injury. Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris. We do not endorse non-Cleveland Clinic products or services. Tolentino S, Pereira MN, Cunha-Filho M, et al. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. Carbohydrate Polymers. However, the natural aging process and exposure to things like ultraviolet radiation from the sun, tobacco smoke, and pollution can decrease its amounts in the skin (2, 3). Hyaluronic Acid: Is It Worth Trying? - Verywell Fit 2021;13(7):2220. doi:10.3390/nu13072220, Marinho A, Nunes C, Reis S. Hyaluronic acid: a key ingredient in the therapy of inflammation. Ingested hyaluronan moisturizes dry skin. Hyaluronic acid, also known as hyaluronan, is a clear, gooey substance that is naturally produced by your body. Research shows that hyaluronic acid is safe to use. What Are the Best Eye Drops for Dry Eyes? When acid reflux occurs, the contents of the stomach are regurgitated up into the throat, causing pain and damage to the lining of the esophagus (27). 2015;98( Suppl 3):S110-S114. With high blood pressure, supplements on your caution list should include: St. John 's wort: Used to treat depression, St. John 's wort speeds up the metabolism of a number of medications. Hyaluronic acid is a remarkable substance because of all the benefits and uses it has in your body. Oral hyaluronic acid is also used in the management of dry eye disease that is caused by loss of tears. Kawada C, Yoshida T, Yoshida H, et al. This site is protected by reCAPTCHA and the Google 2019;33(5):1457-1468. doi:10.1002/ptr.6338. Eye health, especially for treating dry eyes. Taking HA is unlikely to build up in the body at excessive levels. 2020;16(3):366.e1-366.e5. In this case, topical application of hyaluronic acid can increase collagen production and improve the overall appearance of the skin. Savarino V, Pace F, Scarpignato C, Esoxx Study Group. 2016;5(1). It comes in topical, oral, and injectable formsthe latter is considered a medical device. Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period. Here are 10 foods that can help you look and feel your best as you get. https://pubmed.ncbi.nlm.nih.gov/34203487/. Eye drops containing 0.20.4% hyaluronic acid have been shown to reduce dry eye symptoms and improve eye health (32, 33). Additionally, a pilot study looked at the effect of an oral preparation containing hydrolyzed collagen type II, chondroitin sulfate, HA, and hydrolyzed keratin on knee osteoarthritis. For patients who are unable to get enough zinc in their regular diet or who have a need for more zinc, zinc supplements may be necessary. Should I Take Collagen On An Empty Stomach - StomachGuide.net All rights reserved. Furthermore, your bodys natural production of hyaluronic acid may decrease with age. Hyaluronic acid is also found in the joints, where it keeps the space between your bones lubricated (22). While theres little proof that it works as an anti-aging cosmetic product, you can get it injected into your face -- a treatment called a dermal filler -- to lessen wrinkles and add fullness. doi:10.1186/s13643-016-0363-9, Gocmen G, Aktop S, Tzner B, Goker B, Yarat A. The people in these studies don't consume hyaluronic acid directly . A randomized controlled study of 100 people with osteoarthritis of the first carpometacarpal (thumb) joint showed that the intra-articular (within the joint) HA injections were superior to betamethasone (a corticosteroid) injections in improving joint function and pain. Taking hyaluronic acid supplements may prevent this decline by giving your body extra amounts to incorporate into the skin (4, 5). Glucosamine is a sugar that helps your body produce cartilage, while chondroitin helps to maintain flexibility. Similarly, its best to get a joint effusion (too much fluid in your knees) treated before you use hyaluronic acid. One study showed people who took hyaluronic. 2 6 Choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF, when possible. Allergic reactions might occur but are rare. Kim Y, Moon CH, Kim B-Y, Jang SY. 2020;53(8):e9886. Biomolecules. Here are some science-backed benefits oral hyaluronic acid can offer. https://pubmed.ncbi.nlm.nih.gov/34951587/. As an Amazon Associate I earn from qualifying purchases. Other benefits of HA include alleviating acid reflux symptoms and promoting wound healing. Taking hyaluronic acid by mouth can have many benefits. Side Effects of Hyalgan (hyaluronic acid) - MedicineNet Your doctor might suggest hyaluronic acid injections, or gel injections, to ease the pain. In a randomized, double-blind, multicenter study of 168 people with chronic leg ulcers of venous or mixed (venous and arterial) origin, the treatment with 0.2% HA cream daily for 20 weeks resulted in a higher healing rate than a neutral comparator cream. Hyaluronic acid benefits include use for arthritis, joint pain, osteoarthritis, and damaged tissue. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Hyaluronic acid is said to relieve joint pain and symptoms of arthritis. Some . doi:10.1186/s12937-016-0130-8, Singhal S, Hasan N, Nirmal K, et al. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Computational and Mathematical Methods in Medicine. Whats more, its effective at reducing gum disease, speeding up healing after tooth surgery, and eliminating ulcers when used topically in the mouth (21). While the causes of interstitial cystitis are unknown, hyaluronic acid has been found to help relieve the pain and urinary frequency associated with this condition when inserted directly into the bladder through a catheter (46, 47, 48). Tissue masks and under-eye patches are usually impregnated with intense moisturisers such as hyaluronic acid, but they can also be permeated with collagen. Some research shows that pairing oral hyaluronic acid supplements with injections can help extend pain-relieving benefits and increase the amount of time between shots (26). By clicking Accept All, you consent to the use of ALL the cookies. It holds onto moisture and keeps tissues and joints lubricated. Get useful, helpful and relevant health + wellness information. However, negative reactions are mostly associated with the injection procedure, rather than hyaluronic acid itself (1). doi:10.1016/j.clcc.2021.11.008, Di Cicco M, Peroni D, Sepich M, Tozzi MG, Comberiati P, Cutrera R. Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications. It can be used twice a day if you apply it to clean, damp skin, then lock it in with a face oil. They can help you better understand any potential concerns. 2018;48(2):168-175. doi:10.1016/j.semarthrit.2018.01.009, Jang KM, Park YG, Choi WK, et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778932/. Hyaluronic acid supplements taken by mouth are also considered safe (but you should still tell your healthcare provider about them, as you would for any other medication, vitamin or supplement). The evidence suggests that hyaluronic acid helps with soft tissue growth, prompts your body to make more collagen and elastin, keeps your skin moisturized, prevents tightness, boots elasticity, and reduces scarring. 2015;22(1):55-62. doi:10.1111/srt.12228, Abdallah MM, Fernndez N, Matias AA, Bronze M do R. Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Their need for painkillers also went down. Since HA was used in combination with chondroitin sulfate, the effect of HA alone when combined with PPI therapy is unclear. In addition, hyaluronic acid eye drops are frequently used during eye surgery to reduce inflammation and speed wound healing (37, 38). Jpn J Ophthalmol. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. Systematic Reviews. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. This substance is naturally found in many areas of the human body, including the skin, eyes, and synovial fluid of the joints. Apple cider vinegar may be helpful for weight loss in small, indirect ways. See additional information. Yet, one limitation is that it is not known whether the statistical significance of the beneficial effects of HA drops compared with non-HA-based eye drops implies clinical improvement. Make sure that you get a nice exfoliating cleanser, a hydrating cleanser, or a pH balancing cleanser. Home Supplements Hyaluronic Acid Benefits: Skin Care and More! (https://pubmed.ncbi.nlm.nih.gov/30287361/). 2019;7(3):495-499. doi:10.3889/oamjms.2019.086. Stop everyday joint aches from slowing you down with powerful antioxidants, advanced collagens, and hyaluronic acid.*. Reactions or adverse effects from hyaluronic acid are rare, and it's safe to use if you're pregnant or nursing. Peanpadungrat P. Efficacy and safety of fish oil in treatment of knee osteoarthritis. Hyaluronic acid is widely used as an ingredient in fillers that repair or conceal scars left behind by acne. Its especially useful for reducing the appearance of wrinkles and age lines. Carnosine Benefits, Side Effects, Uses, Interactions and More - Dr. Axe European Journal of Obstetrics & Gynecology and Reproductive Biology. How does hyaluronic acid interact with other products? J Med Assoc Thai. (https://pubmed.ncbi.nlm.nih.gov/31715233/). Applying hyaluronic acid directly to an open wound can help speed up the recovery process. Alimentary pharmacology & therapeutics. Since HA has a thick and sticky consistency and retains moisture, it helps the knee joint move smoothly and moisturizes the skin. When applied to the skin: Hyaluronic acid is likely safe. 2018;38(8):1413-1428. doi:10.1007/s00296-018-4077-2, Lugo JP, Saiyed ZM, Lane NE.