apoptosis impact factor 2022
1Research and Advances in Molecular and Cellular Immunology, Center of Biomedical Research, University of Granada, Armilla, 18016 Granada, Spain; moc.liamg@orartecireip, 2Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, 18071 Granada, Spain, 3Childrens Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; ac.no.oehc@eiznekcam, 4Instituto de Investigacin Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, 18014 Granada, Spain, 5Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada, 6Institute of Nutrition and Food Technology Jos Mataix, Biomedical Research Center, University of Granada, Armilla, 18016 Granada, Spain, 7Department of Cell Biology, School of Sciences, University of Granada, 18071 Granada, Spain. Furthermore, recent evidence demonstrating new immune-modulatory functions of IAPs, in both innate and adaptive immunity, opens new doors in terms of therapeutic opportunities. It is composed of three effector mechanisms that can lead to adaptation, survival or apoptosis, respectively, and depends on stimulus and cell type. Crystallogr. Along these lines, survivin expression was observed in 98% of the samples and protein and mRNA levels were shown to be higher than any other IAP measured in these patients. [53], appear to suggest an influence of survivin in OS that is stronger than that of XIAP, although further studies assessing how the presence of individual IAPs affect treatment and CR achievement are clearly required [48,50,53]. IAPs patterns of expression in other malignancies, such as bladder, lung or renal cancers, are similar to those presented above and have been further developed by Fulda and Vucic [90] and Che et al. Indeed, Bv6 was found to synergize with IFN- in the promotion of necroptosis in a TNF- independent manner [18]. Nevertheless, an important observation was made by Kearney et al. Furthermore, xenograft models of MDA-MB-231 cell line had efficient induction of caspase-8 dependent apoptosis with a reduction in cIAP1 levels [113]. Impact Factor of the Journal in 2022 = 500/100 = 5. Apoptosis : an international journal on programmed cell death Faktor Dampak 2021-2022 | Analisis, Kecenderungan, Peringkat & Ramalan Faktor Dampak Apoptosis : an international journal on programmed cell death 2021-2022 adalah 4.677. It was assessed in leukemia and hepatocellular carcinoma cell lines inducing cell death. Ward G.A., Lewis E.J., Ahn J.S., Johnson C.N., Lyons J.F., Martins V., Munck J.M., Rich S.J., Smyth T., Thompson N.T. Da Huang (Rhei Radix et . However, there is limited information regarding the contribution of both mechanisms to actual increases in IAP expression in specific cancer types. Tumor size, extranodal extension, triple-negative status and poorly differentiated subtypes showed direct associations with XIAP expression in the Middle Eastern population. The two years line is equivalent to journal impact factor (Thomson Reuters) metric. Furthermore, although it is normally started as a response to ER stress to alleviate potential proteotoxicities, its pro-survival capacity can contribute to tumorigenesis and cancer progression [132,133]. Ponnelle T., Chapusot C., Martin L., Bonithon-Kopp C., Bouvier A.M., Plenchette S., Rageot D., Faivre J., Solary E., Piard F. Subcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: Relationships with clinicopathological features and prognosis. Indeed, the avoidance of programmed cell death is a characteristic hallmark in cancers. Indeed, the simultaneous engagement of three processes has been termed PANoptosis [22]. Despite all that, when tested in combination with different anticancer agents, Smac mimetic-based therapy showed synergizing effects and led to remission in many cases [19,20]. As outlined above, cancers are not the only pathologies affected by IAP dysregulation. (in 2022) 10,276 Altmetric mentions . It depends on the assembly of complex I and relies on the phosphorylation of IkB (NF-B inhibitor) by IKK. The latest evidence supporting the role of IAPs in some death-resistant cancers and cancer progression are reviewed next. The nomenclature, length, and domains of the different proteins are shown. The development of compounds that mimic the action of Smac showed promise in the re-sensitization of the cell suicide defense mechanism in cancer cells, particularly in combination with other treatments. Lack of activity, obesity, high-fat diet as well as alcohol and smoking are all risk factors for sporadic CRC. MDA-MB231 breast cancer xenograft mouse models benefited from antitumor activity in vivo when GDC-0152 was administered orally as a single agent. Both survivin and livin are normally expressed during fetal development and not in adult tissues [41]. Additionally, data obtained from mRNA levels must be assessed and compared to those of protein in both adult and child populations in order to validate these IAPs as prognostic factors. However, cytokine levels, such as TNF- augmented in circulation and cIAP1 degradation, were observed. Media Ranking in Netherlands. Overall, this supports the evaluation of combination therapy in cancers, in which no therapeutic approach has provided positive results on its own. Ma O., Cai W.-W., Zender L., Dayaram T., Shen J., Herron A.J., Lowe S.W., Man T.-K., Lau C.C., Donehower L.A. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. In this regard, the multiplicity of pathways in which IAPs participate and, most importantly, their abnormal function, due to dysregulation in IAP expression, may add to the pathogenesis of diseases, such as cancer. However, in these same conditions, the alternative pathway is activated, due to lack of destruction of NIK, which allows activation of non-canonical NF-B complexes. Lack of tumoral TNF- production and sensitivity was identified as a possible cause for the low efficacy obtained. On the other hand, second mitochondrial-derived activator of caspases (Smac), the second mitochondrial-derived activator of caspases, also known as DIABLO, is a mitochondrial protein released to the cytosol upon apoptotic stimuli that antagonizes IAPs endogenously, leading to the activation of caspases and the promotion of programmed cell death in normal conditions [17]. Evidence of Birinapants efficacy has been modest but promising. official website and that any information you provide is encrypted Cekay M.J., Roesler S., Frank T., Knuth A.-K., Eckhardt I., Fulda S. Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. Similar to XIAP expression, survivin expression has been correlated with worse clinicopathological features, such as metastasis, and advanced stage, or size, of the tumor. However, there is evidence pointing towards a possible relationship between ER stress and Smac mimetics effectivity that cannot be ignored by future evaluations. Greer R.M., Peyton M., Larsen J.E., Girard L., Xie Y., Gazdar A.F., Harran P., Wang L., Brekken R.A., Wang X. SMAC Mimetic (JP1201) Sensitizes NonSmall Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-Independent Manner. Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: Results of a first-in-man study. [62], it becomes apparent that the tumor microenvironment might have a role in these differences [62]. The NF-B alternative pathway can be initiated by the stimulation of BAFFR, CD40, HTLV or EBV and activates non-canonical NF-B complexes. Accumulation of NIK activates IKK which, in turn, phosphorylates NF-B 2 (p100), transforming it into p52 and allowing nuclear translocation of the p52-RelB heterodimer [45,46]. Zhang et al. HHS Vulnerability Disclosure, Help Upon IAPs downregulation by antisense oligonucleotides both in vitro and in vivo, pre-clinical resistant cell models are able to engage in the apoptotic programs [36]. Additionally, studies aiming for validation of these markers show small sample sizes, have data interpretation limitations and lack standard methodologies causing reproducibility challenges [69]. Apoptosis has since been recognized and accepted as a distinctive and important mode of "programmed" cell death, which involves the genetically determined elimination of cells. IAPs: Whats in a name? Despite these barrier, promising advances are being made. - Article ID 9078475. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Interestingly, in vitro studies with multiple myeloma cell lines observed resistance to LCL161, while in vivo they were sensitive to it [106,107,108]. The Inhibitor of Apoptosis (IAP) family possesses the ability to inhibit programmed cell death through different mechanisms; additionally, some of its members have emerged as important regulators of the immune response. Shin S., Sung B.-J., Cho Y.-S., Kim H.-J., Ha N.-C., Hwang J.-I., Chung C.-W., Jung Y.-K., Oh B.-H. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and-7. Hurwitz H.I., Smith D.C., Pitot H.C., Brill J.M., Chugh R., Rouits E., Rubin J., Strickler J., Vuagniaux G., Sorensen J.M. The two main signaling cascades that activate NF-B can be classified either as classical (canonical) or alternative (non-canonical) pathways. D Biol. Flygare J.A., Beresini M., Budha N., Chan H., Chan I.T., Cheeti S., Cohen F., Deshayes K., Doerner K., Eckhardt S.G. A phase I study on solid tumors revealed good tolerability but poor efficacy [110]. Studies have revealed that long-term exposure to high levels of saturated fatty acids (e.g. Interaction with other molecules, such as tumor necrosis factor-, in the tumor microenvironment reveals a complex interplay between IAPs and cancer. A meta-analysis encompassing 15 studies, with a total of 2202 breast cancer patients, confirmed significant associations between positive expression of survivin and worse OS [88]. It is the most common cancer among women and the second most common cause of mortality in this population. Song Z., Yao X., Wu M. Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis. Altogether, available data suggest a strong link between IAP-mediated apoptosis inhibition and ER stress induction, although it remains unclear whether the UPR apoptosis program contributes or not (and to what extent) to cell death promoted by Smac mimetics treatment [135]. Q1 (green) comprises the quarter of the journals with the highest values, Q2 (yellow) the second highest values, Q3 (orange) the third highest values and Q4 (red) the lowest values. Tamm I., Kornblau S.M., Segall H., Krajewski S., Welsh K., Kitada S., Scudiero D.A., Tudor G., Qui Y.H., Monks A. Indeed, cutoff values for the expression of the BIRC6 gene were observed to be potent prognostic metrics for both poor clinical outcomes and worse response to therapy [60,61]. In 2007, Hess et al. The ISSN (online) number for Oncogenesis is 2157-9024. However, in humans, defective expression of XIAP, due to deleterious mutations, is found to cause X-linked lymphoproliferative syndrome (XLP) type 2 [35,36]. However, the role of apoptosis in thrombopoiesis has been controversial for many years. Ismail E.A.R., Mahmoud H.M., Tawfik L.M., Habashy D.M., Adly A.A.M., El-Sherif N.H., Abdelwahab M.A. The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. In both studies, apollon was identified as a promising prognostic factor due to its association with a higher risk of relapse, worse response to chemotherapy and decreased survival. Promising results were observed when evaluated in combination with paclitaxel; although toxicity was highlighted as an important and limiting factor in the therapeutical scope. Severe adverse events included anemia, and increased lipase and lymphopenia, which were observed, but only in seven patients. American Journal of Biochemistry and Biotechnology, 18 (3), 308-318. https://doi.org/10.3844/ajbbsp.2022.308.318 Dysregulated apoptosis is often observed in other pathological conditions, such as neurodegenerative disorders (Alzheimers Disease, motor system disorders, stroke and many others) or autoimmune diseases (type I diabetes, multiple sclerosis, rheumatoid arthritis and more) [3,4]. Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors. During the last decades, the Unfolded Protein Response (UPR) to ER stress has been systematically studied and associated with cancer pathogenesis [131]. CIAPs, on the other hand, inhibit caspases-3 and -7 by targeting them for proteasomal degradation through the addition of poly-Ub chains, by the action of their RING finger domains [32]. In addition to E3 ligase activity targeting other proteins for degradation, the three IAPs also share autodegradative capacity [34]. [13], described the role of livin in cancer cell migration and invasion by means of the activation of Akt signaling and the induction of EMT in vitro and in vivo [13]. Additionally, Hu et al. Along these lines, reduction of IAP levels can potentially re-sensitize cells to apoptosis. Che X., Yang D., Zong H., Wang J., Li X., Chen F., Chen X., Song X. Similar results have been obtained when assessing BV-6s and Debbio 1143s efficacies [119,120]. Instead, NAIP displays a nucleotide-binding oligomerization domain (NOD), which, together with the BIR domains, allows its participation in the inflammasome assembly in cooperation with NLRC4. As already stated, IAPs inhibition with Smac mimetics has demonstrated some clinical relevance, although their effectiveness has been limited when assessed as individual agents. Phosphatidylserine on the apoptotic cell surface, which . In addition, ER and progesterone receptor-negative hormonal status was observed in to correlate with survivin level [85]. In addition to apoptosis, necrosis can also be promoted by IAPs. The ablation of IAPs in Hu and colleagues experiments did not completely decrease cell survival, indicating the contribution of other pathways in IAP upregulation. Colorectal cancer (CRC), also known as bowel cancer, was the third most diagnosed cancer, and the second most fatal, worldwide in 2018, according to Las cifras del cancer report from the SEOM (Sociedad Espaola de Oncologa Mdica). Aguilar C., Latour S. X-linked inhibitor of apoptosis protein deficiency: More than an X-linked lymphoproliferative syndrome. Cheung H., St Jean M., Beug S., Lejmi-Mrad R., LaCasse E., Baird S., Stojdl D., Screaton R., Korneluk R. SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds. Many cancers demonstrate evasion of apoptosis enhancing cell survival [].Alteration in structure, expression, or even epigenetic regulation of genes, such as TP53 or BCL2 and the caspase-family of genes (or their products) leading to a dysregulated apoptotic process, are classically involved in this hallmark of cancer [].Dysregulated apoptosis is often observed in other . Nuclear Factor Erythroid-2-Related Factor 2 (Nrf2) Signalling Pathway and Apoptosis Impact on the Effect of Tetramethylpyrazine against H2O2-Damage in Human Hepatic Cell Line (LO2 Cells). Likewise, Zhu et al. ISSN 2157-9024 (online). The classical NF-B pathway is pushed towards caspase-8 dependent apoptosis through the formation of RIPK-FADD-Caspase-8 complex and it is fed by the production of TNF- in the alternative pathway. Purroy et al. Translational and posttranslational regulation of XIAP by eIF2 and ATF4 promotes ER stressinduced cell death during the unfolded protein response. The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Debio 1143 is capable of synergizing with taxanes, among other agents, against lung adenocarcinoma cells, even reducing the tumor volume in mice xenografts [139]. cIAP1 is most frequently expressed in nucleus while cIAP2 in the cytoplasm. Carter B.Z., Kornblau S.M., Tsao T., Wang R.Y., Schober W.D., Milella M., Sung H.G., Reed J.C., Andreeff M. Caspase-independent cell death in AML: Caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis.